ISSN 1662-4009 (online)

ey0016.15-10 | (1) | ESPEYB16

15.10. Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons

Furigo Isadora C , Teixeira Pryscila DS , de Souza Gabriel O , Couto Gisele CL , Romero Guadalupe Garcia , Perello Mario , Frazao Renata , Elias Lucila L , Metzger Martin , List Edward O , Kopchick John J , Donato J

To read the full abstract: Nature Communications, 2019; 10 (1); 662This paper highlights the brain as a key target for growth hormone (GH) signaling affecting mostly energy conservation. To identify GH response neurons, C57BL/6 mice received intraperitoneal injection of saline or GH and their brains were processed to detect the phosphorylation of pSTAT5 as a marker of GH receptor a...